In view of the gaps in sensitivity and accuracy and the importance of precise diagnosis to prevent maternal and fetal complications, there is still the need to find other affordable, more sensitive and more accurate biochemical marker/s that will help in diagnosing PROM especially in difficult cases.Ĭreatinine nitrazine specificity sensitivity urea.Ĭopyright: © International Journal of Health Sciences. This was followed by creatinine and then urea. Tests are often done during the third trimester of pregnancy. Excessive amounts can indicate fetal distress or blood compatibility issues between mother and baby. Nitrazine strip was the most reliable of the three in the diagnosis of PROM. Short answer amniotic fluid test strips: Test strips used to measure levels of bilirubin in amniotic fluid. 2pcs Amniotic Fluid Test Strips, Litmus pH Range Test Strips, PH Indicator Test Strips with Amniotic Fluid Control Chart, Maternity Home High Sensitivity Female PH Test StTypical: 13.99 12. Predictive ability of urea at >12.7 mg/dl obtained as cutoff value from the ROC curve showed a sensitivity of 19.64% and specificity of 94.44% while for creatinine the cutoff value was at >0.8 mg/dl with sensitivity of 48.21% and specificity of 65.28%. Nitrazine test showed high level of specificity (100%) but a sensitivity of 87.5%. Statistical analysis was done using SPSS version 23.0 and setting statistical significance at P ≤ 0.05. Receiver Operating Characteristic (ROC) curves were plotted to determine cutoff values for urea and creatinine. PRINCIPLE Microscopic examination of vaginal fluid: Amniotic fluid crystallizes in a fernlike pattern when left to dry on a glass slide. The test is often used in conjunction with vaginal pH. Vaginal fluid aspirates from both groups of patient were tested for urea, creatinine, and pH levels using nitrazine strip. Detection of fern-type amniotic fluid crystallization is used as an aid in detection of ruptured amniotic membranes in pregnant patients. Sixty-four pregnant women with demonstrable passage or pooling of liquor par vaginum on speculum examination and 64 with no liquor drainage at 28-42 weeks gestation were studied. Nitrazine strip measures pH levels while urea and creatinine are produced mainly in amniotic fluid and not in the maternal vagina. The study compared the reliability of nitrazine, urea, and creatinine in the diagnosis of premature rupture of membrane (PROM).
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